Endocrine Abstracts

Introduction: RAGE activation plays a pivotal role in the pathogenesis of diabetic vasculopathy, however the signal transduction mechanism downstream of RAGE is not fully understood. Yoshimoto et al. previously established the RAGE-overexpressed vascular smooth muscle cell line, RAGE-A10, and found that its slow growth rate and increased monocyte chemotactic protein-one (MCP-1) mRNA expression were analogous to the phenomenon of senescence. Senescent cells display characterist...

Objective: Osteoporosis and osteopenia (OS/OP) are frequent in patients with cortisol-producing adrenal adenomas (CPA) associated with severity of cortisol excess (CE). However, the relationship between OS/OP and CE severity considering sex differences is unknown.Patients and Methods: This was a retrospective cross-sectional observational study conducted as a part of the Advancing Care and Pathogenesis of Intractable Adrenal Disease in Japan (ACPA-J) stu...